Jesse Montgomery (Ashton Kutcher) and Chester Greenburg (Seann William Scott) are hard-partying pizza-delivery dudes who wake up one morning with no recollection of what happened the previous night -- including where they parked Jesse's car! As they try to retrace their steps, they get mixed up with latex-clad transsexual strippers, a pot-smoking dog, invading aliens ... and angry ostriches!