Brothers Matt (Eric Lively) and John (Oliver Hudson), their girlfriends, Sara (Taryn Manning) and Nicki (Michelle Rodriguez), and pal Noah (Hill Harper) are looking for a little RandR when they jet off for a week's vacation on a deserted island. What they get instead is terror when a pack of crazed canines makes them prey. Outnumbered (and very nearly outwitted), the group must fight off the genetically engineered killers.